Abstract

The results of dermatological research and therapy with topically applied medications are influenced by several factors among which the total amount applied and the specific area of application are important ones. These factors are often neglected or ignored in favor of concentration of active ingredient, rate of percutaneous absorption and frequency with which the preparations are applied. This disparity in emphasis has doubtless ensued because most topical treatments are performed by the subjects or patients and as such are at best indirectly controlled by the investigator.

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