The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval: A multisite electrophysiological study in rats.

Abstract

Event Abstract Back to Event The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval: A multisite electrophysiological study in rats. Nadine Ravel1*, Samuel Garcia1, Belkacem Messaoudi1, Marc Thevenet1, Guillaume Ferreira2, Remi Gervais1 and Julie Chapuis1 1 UMR CNRS-Lyon1 5020, France 2 Tours University, UMR INRA 85 - CNRS 6175, France Recent findings have revealed the importance of orthonasal and retronasal olfaction in food memory, especially in conditioned odor aversion (COA); however, little is known about the dynamics of the cerebral circuit involved in the recognition of an odor as a toxic food signal and whether the activated network depends on the way (orthonasal versus retronasal) the odor was first experienced. In this study, we mapped the modulations of odor-induced oscillatory activities through COA learning using multisite recordings of local field potentials in behaving rats. During conditioning, orthonasal odor alone or associated with ingested odor was paired with immediate illness. For all animals, COA retrieval was assessed by orthonasal smelling only. Both types of conditioning induced similarly strong COA. Results pointed out (i) a predictive correlation between the emergence of powerful beta (15-40 Hz) activity and the behavioral expression of COA and (ii) a differential network distribution of this beta activity according to the way the animals were exposed to the odor during conditioning. Indeed, for both types of conditioning, the aversive behavior was predicted by the emergence of a strong beta oscillatory activity in response to odor in the olfactory bulb, anterior and posterior piriform cortex, orbitofrontal cortex, and basolateral amygdala. This network was selectively extended to the infralimbic and insular cortices when the odor was ingested during COA learning. These differential networks could participate in different food odor memory; these results are discussed in line with recent behavioral results that indicate that COA can be formed over long odor-illness delays only if the odor is ingested. This work was supported by the CNRS, by the Minist Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Ravel N, Garcia S, Messaoudi B, Thevenet M, Ferreira G, Gervais R and Chapuis J (2009). The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval: A multisite electrophysiological study in rats.. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.241 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Jun 2009; Published Online: 12 Jun 2009. * Correspondence: Nadine Ravel, UMR CNRS-Lyon1 5020, Lyon, France, nadine.ravel@cnrs.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nadine Ravel Samuel Garcia Belkacem Messaoudi Marc Thevenet Guillaume Ferreira Remi Gervais Julie Chapuis Google Nadine Ravel Samuel Garcia Belkacem Messaoudi Marc Thevenet Guillaume Ferreira Remi Gervais Julie Chapuis Google Scholar Nadine Ravel Samuel Garcia Belkacem Messaoudi Marc Thevenet Guillaume Ferreira Remi Gervais Julie Chapuis PubMed Nadine Ravel Samuel Garcia Belkacem Messaoudi Marc Thevenet Guillaume Ferreira Remi Gervais Julie Chapuis Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.