Abstract
Accurate wound repair is a crucial step to protect organisms from environmental damage, for example infection and toxin exposure. In this issue of The EMBO Journal, Miyoshi et al (2017) have elucidated a new mechanism underpinning this process within the intestine where mesenchymal prostaglandin E2 produced following damage drives intestinal regeneration.
Highlights
Accurate wound repair is a crucial step to protect organisms from environmental damage, for example infection and toxin exposure
Given repair/wound healing often activates many pathways deregulated in cancer, for example WNT and TGFb, uncontrolled repair and loss of homoeostasis could lead to carcinogenesis (Ashton et al, 2010)
The healing process is most likely to be performed by a cell population that has transient repair features, wound-associated epithelial (WAE) cells, and the induction of non-canonical Wnt signalling is required (Stappenbeck & Miyoshi, 2009)
Summary
Accurate wound repair is a crucial step to protect organisms from environmental damage, for example infection and toxin exposure. Given repair/wound healing often activates many pathways deregulated in cancer, for example WNT and TGFb, uncontrolled repair and loss of homoeostasis could lead to carcinogenesis (Ashton et al, 2010). To guarantee proper wound repair, a process termed epithelial restitution occurs in the intestine to rapidly reseal superficial injuries (Lacy, 1988). The healing process is most likely to be performed by a cell population that has transient repair features, wound-associated epithelial (WAE) cells, and the induction of non-canonical Wnt signalling is required (Stappenbeck & Miyoshi, 2009).
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