The volatile fatty acids indicators in the differential diagnosis of purulent complications of pancreatic necrosis.

Abstract

The purpose of the study was to evaluate the informative value of volatile fatty acid (VFA) indicators for the differential diagnosis of infected pancreatic necrosis (IPN), complicated by retroperitoneal cellulose phlegmons and IPN, complicated by pancreatic abscesses. The work is based on the results of the examination and treatment of 52 patients with IPN, complicated by abscesses and phlegmon. The analysis of the concentrations of acetic, propionic, butyric and isovaleric acids were carried out on the gas chromatograph "Crystalllux-4000" with the capillary "HP-FFAP" column. Indicators of acetic, propionic, butyric acids and the amount of VFA were statistically significantly higher in patients with IPN, complicated by retroperitoneal cellulose phlegmons, compared with those of VFA in patients with IPN, complicated by pancreatic abscesses. Indicators of acetic acid and the amount of VFA were statistically significantly higher in patients with IPN, complicated by parapancreatic phlegmon, compared with those of VFA in patients with IPN, complicated by pancreatic abscesses. Indicators of acetic, propionic, butyric, isovaleric acid and the amount of VFA were statistically significantly higher in patients with IPN, complicated by paracolic phlegmon, compared with atients with IPN, complicated by pancreatic abscesses. Indicators of acetic, propionic, butyric acids and the amount of VFA were statistically significantly higher in patients with IPN, complicated by total retroperitoneal phlegmon, compared with patients with IPN, complicated by pancreatic abscesses. The values of VFA can be used as additional criteria for the differential diagnosis between IPN, complicated by retroperitoneal phlegmon and IPN, complicated by pancreatic abscess.