The vitamin- D quantity versus bone quality: A logistic based regression modeling in Jordanian cohort who at higher risk of osteoporotic fracture

Abstract

Background: Several studies validated the positive impacts of Cholecalciferol derivatives; including dietary and non-dietary sources, on the bone architectural contents and the overall skeleton densities. We primarily aimed in this study to explore the optimal thresholds for the studied patients’ 25-OH Cholecalciferol levels that are correlated with the higher probabilities for having lumbar bone mineral density (LBMD) exceeding 0.835 g per cm2 and femoral hip bone mineral density (fH_BMD) exceeding 0.755 g per cm2. Methods: An observational retrospective study was conducted for patients, who are at risk of osteoporotic fracture, Firstly, a Binary Logistic Regression analysis was separately conducted for the investigated patients’ vitamin D levels against the patients’ fH_BMD ≥0.755 (Positive state) vs <0.755 (Negative state) and against the patients’ LBMD≥ 0.835 (Positive state) vs <0.835 (Negative state). Both the Receiver Operating Characteristic and the Sensitivity analyses were thereafter be conducted and the performances indices were explored. Results: Our constructed BLgR models, that logistically integrated the binary correlation between the investigated patients’ Vit D levels and their femoral hip or lumbar bone mineral densities, respectively, were constructed as [= e (--1.455+0.109× Vit D) /1+ e (--1.455+0.109× Vit D)] or [= e (--22.127+0.829× Vit D) /1+ e (--22.127+0.829× Vit D)], respectively. Conclusion: The optimal Vitamin D levels for our investigated Jordanian cohort to have a higher probability of lumber and femoral hip bone mineral; densities were identified at 27.05 ng/ml and 27.25 ng/ml, respectively.