The vitamin B12 content of human liver as determined by bio-assay of needle biopsy material.

Abstract

Article1 December 1958THE VITAMIN B12 CONTENT OF HUMAN LIVER AS DETERMINED BY BIO-ASSAY OF NEEDLE BIOPSY MATERIALROBERT S. NELSON, M.D., F.A.C.P., VASANT M. DOCTOR, Ph.D.ROBERT S. NELSON, M.D., F.A.C.P.Search for more papers by this author, VASANT M. DOCTOR, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-6-1361 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe vitamin B12content of human liver postmortem specimens has been previously studied,1, 8and changes have been noted in pernicious anemia in relapse1and in cirrhosis.8These valuable contributions were necessarily of a static nature, and defined the liver vitamin B12content after death in certain patients who could not be followed by serial determinations during life. Studies with radioactive labeled vitamin B122, 4, 5, 7have done much to clarify the relative contents of various body organs and the rate at which absorption takes place from the bowel and parenterally. It has been shown that, in the human,...Bibliography1. Girdwood RH: The occurrence of growth factors for Lactobacillus leichmannii, Streptococcus faecalis and Leuconostoc citrovorum in the tissues of pernicious anemia patients and controls, Biochem. J. 52: 58, 1952. CrossrefMedlineGoogle Scholar2. GlassBoydGellin GBLJGA: Surface scintillation measurements in humans of the uptake of parenterally administered radioactive vitamin B12 , Blood 10: 95, 1955. CrossrefMedlineGoogle Scholar3. GrosswiczHochmanAronovitchIzakRachmilewitz NAJGM: Malignant growth in the liver and serum-vitamin B12 levels, Lancet 1: 1116, 1957. CrossrefGoogle Scholar4. HeinleWelchScharfMeachanPrusoff RWADVGCWH: Studies of excretion (and absorption) of Co60-labeled vitamin B12 in pernicious anemia, Tr. A. Am. Physicians 65: 214, 1952. MedlineGoogle Scholar5. MeyerBerlinJiminez-CasadoArkun LMNIMSN: Vitamin B12 distribution determined by surface body counting following parenteral administration of Co60 vitamin B12 , Proc. Soc. Exper. Biol. and Med. 91: 129, 1956. CrossrefMedlineGoogle Scholar6. Nelson RS: The development and function of a liver biopsy program: training of personnel, description of a modified Vim-Silverman needle and clinical value of 500 biopsies, Am. J. M. Sc. 227: 152, 1954. CrossrefMedlineGoogle Scholar7. Schilling RF: Recent studies of intrinsic factor and utilization of radioactive vitamin B12 , Federation Proc. 13: 769, 1954. Google Scholar8. SwendseidHvolbollSchickHalsted MEEGJA: The vitamin B12 content of human liver tissue and its nutritional significance, Blood 12: 24, 1957. CrossrefMedlineGoogle Scholar9. ZamcheckSidman NRL: Needle biopsy of liver; its use in clinical and investigative medicine, New England J. Med. 249: 1020, 1953. CrossrefMedlineGoogle Scholar10. ZamcheckKlausenstock NO: Medical progress: liver biopsy; risk of needle biopsy, New England J. Med. 249: 1062, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Houston, Texas*Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 30, 1958.From the Department of Medicine, The University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston, Texas.†This work was supported by grants-in-aid, U. S. Public Health Service, and Institutional Grant from the American Cancer Society.Requests for reprints should be addressed to Robert S. Nelson, M.D., Associate Internist, University of Texas M. D. Anderson Hospital and Tumor Institute, 6723 Bertner, Houston 25, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamin B12Turnover in ManNEUROLOGICAL SYMPTOMS AND SIGNS IN A SELECTED GROUP OF PARTIALLY GASTRECTOMIZED PATIENTS WITH PARTICULAR REFERENCE TO B12 DEFICIENCYNEUROLOGICAL COMPLICATIONS IN AN UNSELECTED GROUP OF PATIENTS PARTIALLY GASTRECTOMIZED FOR GASTRIC ULCERSurvey of vitamin B12and folate in the serum and marrow tissue of hospitalized patientsLaboratory Tests for the Assessment of Nutritional StatusThe long-term relationship between serum vitamin B12 and total body vitamin B12Observations on Folate Metabolism in Rats on a Vitamin B 12 -Deficient DietThe Content of Vitamin B 12 in Adult and Foetal Tissue: A Comparative StudyDie megaloblastischen AnämienVITAMIN B 12 METABOLISM IN THALASSEMIA MAJORValidity of the Assumption of Tracer Equilibrium with respect to the Excretion of Vitamin B 12Liver B12 in Subjects With and Without Vitamin B12 Deficiency. A Quantitative and Qualitative StudyFailure of Long-Term Oral Vitamin B12 Therapy to Replenish Body B12 StoresAssessment of Body Stores of Vitamin B12 During Maintenance Therapy of Pernicious Anaemia with Depot Cyanocobalamin Preparation (Betolvex®)The vitamin B12 content of human liver tissue obtained by aspiration biopsyObservations on the Metabolism of Folic Acid in Pernicious AnaemiaVitamin B12 Content of Liver and Serum in Malignant NeoplasiaHepatic and Serum Vitamin B12 Content in Liver DiseaseCalculations on vitamin B 12 turnover in man with a note on the maintenance treatment in pernicious anemia and the radiation dose received by patients ingesting radiovitamin B 12The Effect of Incubation of Plasma with Russell's Viper Venom on the Recalcification Clotting Time 1 December 1958Volume 49, Issue 6Page: 1361-1367KeywordsAnemiaBiopsyHospital medicineInflammationLactobacillusLiverMedical servicesPernicious anemia ePublished: 1 December 2008 Issue Published: 1 December 1958 PDF downloadLoading ...