Abstract
Human T-cell leukaemia virus (HTLV) has been isolated from several cases of cutaneous T-cell lymphoma in the United States1,2. Subsequently, adult T-cell leukaemia virus (ATLV) was also isolated from several cases of adult T-cell leukaemia in Japan3–5. Since the latter disease has been shown to be correlated ≥90% with the presence of high titred natural antibodies6–8 to two structural proteins of HTLV [p24 (ref. 9) and p19 (ref. 10)], it was important to compare HTLV and ATLV. We report here that by serology of p24 and p19 and by nucleic acid homology, ATLV appears to be as closely related to the original isolate of HTLV as different isolates of HTLV (from various regions of the world) are related to each other. ATLV is therefore either identical or closely related to HTLV.
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