The virulence of glucose non-fermentative organisms in experimental pyelonephritis in mice.

Abstract

The virulence of clinical isolates of Acinetobacter calcoaceticus, Pseudomonas cepacia, and Pseudomonas maltophilia in urinary tract in mice was studied.In general, the virulence of these organisms in urinary tract of normal mice was relatively mild.The effect of anti-inflammatory and immunosuppressive drugs on pathogenicity of these organisms was studied in mice.The mice previously treated with betamethasone or prednisolone as anti-inflammatory drug, and with cyclophosphamide or azathiopurine as immunosuppressive drug, were more susceptible to these bacterial infections than were the non-treated ones.As for the capacity of bacterial attachment to the epithelial cells of the bladder, these organisms were generally shown to have low adhesion.Furthermore, the hemagglutination patterns were mannose-sensitive in human and guinea pig erythrocytes.