Abstract
Previous studies have indicated that intestinal mucosa is compressed in vivo. The present study investigated the contribution of the villi to the biomechanical properties in circumferential direction in the guinea pig jejunum. Eight segments were used in this study. Each 20 cm long segment was excised and separated into two 10 cm long segments. The mucosal villi were scraped off from half the segments. Then the segments were pressurized in vitro with Krebs solution from 0–10 cmH2O using a ramp distension protocol with simultaneous diameter recordings. Circumferential stresses and strains were computed from the diameter, pressure and the zero-stress state data. Removing villi from the mucosa resulted in small opening angles (139±16 vs 189±27 with villi) and absolute value of residual strain (inner: −0.05 ± 0.03 vs −0.33 ± 0.06 with villi; outer: 0.11±0.04 vs 0.33±0.08 with villi) (P<0.001). The stress-strain curve of the segment without villi was located at the left compared to the segment with villi, indicating the wall was stiffer without villi. However, if the villi were not taken into account in the computation of the stress-strain in the intact segment, the curve was only partly shifted to the left. In conclusion, the villi not only affect the zero-stress state conformation but also affect circumferential stresses and strains in the guinea pig jejunum. The research was supported by Aalborg Hospital.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
