Abstract
Meeting abstracts We examined the immune microenvironment of primary colorectal cancer (CRC) using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry and functional analysis of tumor infiltrating lymphocytes. A subset of CRC displayed high infiltration with activated CD8+
Highlights
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints
We examined the immune microenvironment of primary colorectal cancer (CRC) using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry and functional analysis of tumor infiltrating lymphocytes
A subset of CRC displayed high infiltration with activated CD8+ CTL as well as activated Th1 cells characterized by IFN-gamma production and the Th1 transcription factor Tbet
Summary
We examined the immune microenvironment of primary colorectal cancer (CRC) using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry and functional analysis of tumor infiltrating lymphocytes. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints Nicolas L Losa1*, Michael Cruise2, Ada Tam1, Elizabeth Wick1, Elizabeth Hechenbleikner1, Janis M Taube1, Richard Blosser3, Hongni Fan4, Hao Wang4, Brandon Luber4, Ming Zhang4, Nickolas Papadopoulos4, Kenneth Kinzler4, Bert Vogelstein4, Cynthia Sears4, Robert A Anders1, Drew Pardoll1, Franck Housseau4, Nicholas Siegel4
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