Abstract
The ventricular-subventricular zone: a source of oligodendrocytes in the adult brain.
Highlights
Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults
The e-Book “The ventricular-subventricular zone as a source of oligodendrocytes in the adult brain” has collected the most recent evidence regarding the mechanisms that modulate the proliferation, migration, quiescence, cell-fate choices and survival of oligodendrocyte precursors generated in the V-SVZ
This work suggests that signaling through the cascade NMDA receptors (NMDAR)–PKC-NOX2 generates ROS that, in turn, activate the PI3/mTOR pathway and drives oligodendrogenesis
Summary
Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults. The e-Book “The ventricular-subventricular zone as a source of oligodendrocytes in the adult brain” has collected the most recent evidence regarding the mechanisms that modulate the proliferation, migration, quiescence, cell-fate choices and survival of oligodendrocyte precursors generated in the V-SVZ. They analyzed the effects of Sonic hedgehog (Shh) signaling on proliferation and specification of human cortical Olig2+ progenitors in vitro.
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