Abstract
Objective To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS. Methods It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (FeNO). Results Obesity was confirmed for the two groups with a total sample mean value of BMI = 35.06 ± 4.68 kg/m2. A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93 ± 14 vs. 79 ± 12%), an abnormal DLCO (112 ± 20 vs. 93 ± 22%), and higher bronchial inflammation (18.40 ± 9.20 vs. 31.30 ± 13.60 ppb) (p < 0.05). Conclusion Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation.
Highlights
Obesity has reached epidemic proportions worldwide (12% of the world’s population) [1]
Polysomnography in the sleep laboratory remains the main tool for diagnosis of obstructive sleep apnea syndrome (OSAS) [9,10,11]. e OSAS can have many serious consequences: metabolic, behavioral, or cardiovascular [8, 9, 12,13,14,15]. ese latter consequences are common in patients with OSAS, but the underlying mechanisms of this association are unknown
Study Design. is was a cross-sectional study conducted in the physiology and functional exploration laboratory. e studied sample was composed of 48 obese adults divided into two groups: an obese control group (G1, n 25) free from any respiratory disease and an obese OSAS group Journal of Obesity (G2, n 23)
Summary
To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS. It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Obesity was confirmed for the two groups with a total sample mean value of BMI 35.06 ± 4.68 kg/m2. A significant decrease in lung function was noted in patients with OSAS compared with controls. When compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93 ± 14 vs 79 ± 12%), an abnormal DLCO (112 ± 20 vs 93 ± 22%), and higher bronchial inflammation (18.40 ± 9.20 vs 31.30 ± 13.60 ppb) (p < 0.05). Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. is can be explained in part by the alveolar inflammation
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