Abstract
Background/aimCanarium odontophyllum (CO) (Miq.) (Burseraceae) has been traditionally consumed for its antioxidant benefit in maintaining longetivity. However, there is no report concerning its pharmacological activity on blood vessels. This study was aimed to investigate the effects of CO aqueous leaf extract on isolated aortic rings. MethodsIsolated thoracic aortic rings were suspended in a tissue bath and placed between 2 tungsten wires and connected to an isometric force transducer. The tension changes were recorded to a data acquisition system. ResultsThe leaf aqueous extract (3–15 mg/ml) induced relaxation in endothelium-intact and endothelium-denuded aortic rings precontracted with PE. Incubation with nitric oxide enzyme inhibitor L-NAME, however, did not alter the CO-induced vasorelaxant on endothelium-intact aortic ring. The vasorelaxant effect of CO was endothelium-independent as it reduced the contraction induced by extracellular Ca2+ in endothelium-denuded aortic ring precontracted by PE and KCl in Ca2+-free Krebs solution. However, CO did not inhibit the release of intracellular Ca2+ from sarcoplasmic reticulum. ConclusionThis study suggests that the vasorelaxant effect of aqueous extract from CO leaves was endothelium-independent and was possibly mediated through the blockade of voltage-dependent calcium channel and receptor-operated calcium channel.
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