Abstract
Objectives: This research is to measure the prevalence rate of antiplatelet resistance in ischemic stroke patients and measure the vascular risk factors associated with antiplatelet resistance in patients with ischemic stroke.
 Methods and Subjects: This was a cross-sectional study with the number of respondents in this study amounted to 155 patients who all had ischemic stroke disease at Bethesda Hospital in Yogyakarta Indonesia used stroke registry to complete the data of the risk factors. VerifyNow method is used to measure the responsiveness of antiplatelet therapy.
 Results: Among the 155 patients with ischemic stroke, 45 were women (29%), 110 were men (71%), and the elderly (age more than 60 years old) in 81 patients. In total 155 patients with ischemic stroke, 106 of them have hypertensive, with diabetes are 19 patients, dyslipidemia is 90 patients, and ischemic heart disease in 13 patients. The prevalence of antiplatelet resistance in risk factors, for age more than 60 years, is 21 patients (25%, RR=1.06, *p=0.96), in diabetes is 7 patients (36%, RR=1.17, **p=0.74), dyslipidemia is 19 patients (21%, RR=0.68, ***p=0.24), and ischemic heart disease is four patients (30%). Among 127 patients, 22% (28 patients) had aspirin resistance, while from 42 patients, 26.2% (11 patients) were resistant to clopidogrel.
 Conclusion: Antiplatelet resistance is common in ischemic stroke patients. One of five patients treated with antiplatelet showed non-responsiveness. Vascular risk factors do not increase the risk of antiplatelet resistance in ischemic stroke patients.
Highlights
Stroke is defined as an acute focal or global neurological deficit lasting longer than 24 h or leading to death
Aspirin resistance test is performed in 127 patients and clopidogrel test 42 patients
Most patients with age more than 60 years old were 81 patients (52%). This result has a corelation to the study by Spurthi et al Regarding the risk factors, hypertension had the highest percentage of 68%, which was followed by dyslipidemia in 58%, and diabetes mellitus in 19%
Summary
Stroke is defined as an acute focal or global neurological deficit lasting longer than 24 h or leading to death. Stroke is a major cause of mortality and morbidity globally. Stroke is classified in hemorrhagic or ischemic depending on the pathological process responsible. About 87% of all strokes are ischemic strokes [1]. Ischemic stroke is an acute brain infarction or injury resulting from reduced blood supply in areas of the brain [2]. According to the Global Burden of Disease Study in 2017, stoke was found to be the 2nd leading cause of death worldwide having mortality rates of 11.02% per 100,000 population. Ischemic stroke showed mortality rates of 16% per 100,000 population worldwide [3]
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