The variation and significance of interleukin-6 and E-selectin, intercellular adhesion molecule-1 in children with sepsis

Abstract

Objective To investigate the variation of interleukin-6(IL-6), vascular endothelial growth factor(VEGF), E-selectin and intercellular adhesion molecule-1(ICAM-1)in children with sepsis and the clinical significance. Methods This was a prospective and control study.Thirty-two children diagnosed as sepsis in PICU from December 2008 to December 2009 served as the sepsis group.According to whether there was a shock, sepsis group were divided into shock subgroup and no shock subgroup.Fifteen healthy children served as control group.The serum levels of IL-6, VEGF, E-selectin and ICAM-1 were detected with enzyme linked immunosorbent assay. Results The serum level of IL-6 was 65.00(30.49~237.14) ng/L in shock subgroup and 48.68(30.25~75.00) ng/L in no shock subgroup, which were significantly higher than that in control group[0.80(0.60~1.00) ng/L](P<0.05). There was no significant difference between shock subgroup and no shock subgroup.The serum levels of VEGF and E-selectin showed no significant differences among the three groups.The serum level of ICAM-1 was 998.72(666.93~1 526.44) ng/ml in shock subgroup, and 925.71(683.53~1 225.12) ng/ml in no shok subgroup, which were significantly higher than that in control group[660.59(525.48~685.47) ng/ml]. Compared with those who survived in sepsis group, the serum levels of VEGF and E-selectin in the died children with sepsis showed no significant difference, but IL-6 and ICAM-1 significantly increased(P<0.05). Conclusion IL-6 and ICAM-1 increase greatly and accentuate inflammation in septic patients, the changes of which may help to determine the prognosis of sepsis. Key words: Sepsis; Interleukin-6; E-selectin; Intercellular adhesion molecule-1