Abstract
Objective To observe the changes of neoplastic metastasis and the variation of inflammation in the serial passage of the bearing tumor mice and to explore the correlation between inflammation and neoplastic metastasis. Methods The bearing tumor mice was serial passaged to observe lung metastasis in the second,the eighth and the fifteenth generation,immunohistochemistry was used to detect the density of CD68 and the expression of CD31 and SDF-1 on each group.Resluts With the numbers of passage increasing, neoplastic metastasis was gradually enhanced.The density of macrophage and the expression of CD31 and SDF-1 graduallyincrease and the expression of CD31 and SDF-1 were positively correlated to the density of macrophage (P<0.05). Conclusions The LLC's ability of metastasis is gradually enhanced in the process of serial passage in mice and there is important connection between this dynamic variation and inflammation. Key words: Lewis lung cancer; Metastasis; Macrophage; Inflammation
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