Abstract
The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derived from the Health Workers Cohort Study (HWCS) (n = 411). Based on GWAS results, we selected the rs1784042 and rs17120425 SNPs in the SIDT1 transmembrane family member 2 (SIDT2) gene for replication in the entire cohort (n = 1963), using predesigned TaqMan assays. We observed a prevalence of MetS in the HWCS of 52.6%. The minor allele frequency for the variant rs17120425 was 10% and 29% for the rs1784042. The SNP rs1784042 showed an overall association with MetS (OR = 0.82, p = 0.01) and with low levels of high-density lipoprotein (HDL-c) (odds ratio (OR) = 0.77, p = 0.001). The SNP rs17120425 had a significant association with type 2 diabetes (T2D) risk in the overall population (OR = 1.39, p = 0.033). Our results suggest an association of the rs1784042 and rs17120425 variants with MetS, through different mechanisms in the Mexican population. Further studies in larger samples and other populations are required to validate these findings and the relevance of these SNPs in MetS.
Highlights
Metabolic syndrome (MetS) is characterized by a set of metabolic factors that increase the risk of cardiovascular diseases (CVD), type 2 diabetes (T2D) and atherosclerosis [1,2]
This study included a total of 1963 participants from the Health Workers Cohort Study (HWCS); 70% were women and 30% were men
We observed that the men group had higher levels of overweight, waist circumference (WC), smoking, blood pressure (BP), fasting glucose, total cholesterol (TC), TG and lower HDL-c levels than women (p < 0.05)
Summary
Metabolic syndrome (MetS) is characterized by a set of metabolic factors that increase the risk of cardiovascular diseases (CVD), type 2 diabetes (T2D) and atherosclerosis [1,2]. And twin studies have provided the initial evidence for the heritability and co-occurrence of the metabolic traits. MetS heritability has been reported between 13% and 30% and for some individual metabolic components can be as high as 50% [4,5,6]. Several Genome-wide association studies (GWAS) have been performed to identify MetS-related single nucleotide polymorphisms (SNPs) considering independent components of MetS as quantitative traits [7,8,9]. Most variants associated to MetS have been located within or near genes regulating lipid metabolism and seem to be relevant for the genetic background of MetS [10,11,12]. Genetic variants are of great interest when SNPs have different frequencies between populations, because it could lead to differences in gene expression [13]
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