Abstract
ingle-nucleotide polymorphisms (SNPs) in long noncoding RNA (lncRNA) genes are associated with the onset and progression of multiple cancers in humans. These SNPs are potential biomarkers for predicting cancer risk. The variable frequency of the lncRNA prostate cancer-associated noncoding RNA 1 (PRNCR1) rs1456315 C/T polymorphism may affect different ethnic groups differently, however, the information lacks for the Saudi population. The aim of this study was to assess the allelic distribution and frequency of the PRNCR1 rs1456315 C/T polymorphism in the Saudi Arabian population, as well as compare it to other populations around the world. PUBMED (Medline) and other related web-databases were referred to extract data from epidemiological studies performed in different ethnic groups. The frequency of PRNCR1 rs1456315 variant allele (C) was found to be 34.62% and a significantly different frequency was observed for the USA (p=0.01), Iran (p < /em><0.007) and China (p=0.01) ethnicity, when the Saudi occurrence is compared to those populations. Present results reveal a distinct pattern of lncRNA prostate cancer-associated noncoding RNA 1 (PRNCR1) rs1456315 polymorphism variant allele in the Saudi Arabian population, which may be due to ethnic differences. The findings could assist in the risk assessment of people harbouring risk allele of rs1456315 SNP and their subsequent cancer susceptibility.
Highlights
Colorectal cancer results from a combination of epigenetic and genetic changes.The transformation of epithelial cells into colorectal adenocarcinoma could be caused by a variety of biological pathways
The prevalence of the Prostate cancer non-coding RNA 1 (PRNCR1) rs1456315 polymorphism was abstracted from eight studies (AlMutairi et al, 2019; Chung et al, 2011; Li et al, 2016; Li et al, 2013; Li et al, 2021; Salinas et al, 2008; Sattarifard et al, 2017; Xu et al, 2017) and included in the current analysis, which was compared to the Saudi Arabian population
The minor allele frequency (MAF) of the PRNCR1 rs1456315 polymorphism in the Saudi Arabian population was found to be 34.62 percent according to the genotype distribution, which was in accordance with Hardy– Weinberg equilibrium (HWE) (Table 1)
Summary
Colorectal cancer results from a combination of epigenetic and genetic changes. The transformation of epithelial cells into colorectal adenocarcinoma could be caused by a variety of biological pathways. Colorectal cancer's genetic basis is represented as a multistep model of cancer onset and progression (Fearon and Vogelstein 1990). Long noncoding RNAs have been identified as important genetic regulators of a vital biological procedure central to risk of developing cancer and many other diseases. RNA transcripts longer than 200 nucleotides that do not code for any proteins are known as lncRNAs (Costa 2010). Some lncRNAs, such as Prostate cancer non-coding RNA 1 (PRNCR1), HOTAIR, and UCA1, are thought to play a role in the progression of cancer
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