Abstract
Background and objectivesThe atherogenic index of plasma (AIP) is elevated in fatty liver disease, but its value in non-obese people with non-alcoholic fatty liver disease (NAFLD) is unclear. This study aimed to investigate the relationship between AIP and NAFLD as well as to determine whether AIP might be used as an indicator of NAFLD in non-obese individuals.MethodsThe present study involved non-obese Chinese and Japanese participants. Risk factors are evaluated using univariate and multivariate analysis. The performance of risk factors was compared according to the area under the receiver operating characteristic curve.ResultsIn the unadjusted model, the odds ratio (OR) for every 1 standard deviation (SD) increase in AIP was 52.30. In adjusted models I and II, the OR for every 1 SD increase in AIP was 36.57 and 50.84, respectively. The area under the receiver operating characteristic curve for AIP was 0.803 and 0.802 in the development and validation groups, respectively. The best cut-off value of AIP for discrimination between NAFLD and non-NAFLD was 0.005 in the Chinese group and − 0.220 in the Japanese group.ConclusionsAIP and NAFLD are positively correlated in Chinese and Japanese populations. Therefore, AIP can be used as a new screening indicator for non-obese people with NAFLD in different nations.
Highlights
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide
Variables included in the Chinese database file were as follows: age, sex, γglutamyltranspeptidase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB), globulin (GLB), total bilirubin (TB), direct bilirubin (DBIL), blood urea nitrogen (BUN), creatinine (Cr), estimated glomerular filtration rate, uric acid (UA), low-density lipoprotein cholesterol (LDLc), fasting plasma glucose (FPG), high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), triglyceride (TG), body mass index (BMI), atherogenic index of plasma (AIP) and fatty liver
The average age, TP, ALB, GLB, TB, BUN, Cr, estimated glomerular filtration rate (eGFR), UA, FPG, TC, Low-density lipoprotein cholesterol (LDL-c) and BMI were greater in patients with than without non-alcoholic fatty liver disease (NAFLD)
Summary
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide. Obesity is an important risk factor for NAFLD [3]. The plasma atherosclerosis index (AIP) is a quantitative indicator used to evaluate blood lipid levels. AIP has good predictive value for dyslipidemia diseases such as diabetics, atherosclerosis and heart disease [7,8,9]. AIP has important predictive value for cardiovascular disease and for hyperuricemia [10]. The atherogenic index of plasma (AIP) is elevated in fatty liver disease, but its value in non-obese people with non-alcoholic fatty liver disease (NAFLD) is unclear. This study aimed to investigate the relationship between AIP and NAFLD as well as to determine whether AIP might be used as an indicator of NAFLD in non-obese individuals
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
