Abstract
BackgroundThe prognostic value and optimal resection outcome related factors of the secondary cytoreduction surgery (SCR) in Platinum-sensitive recurrent ovarian cancer (PSOC) patients were still in doubt. The present retrospective study aims to determine the relationship between the objective response of secondary neo-adjuvant chemotherapy (SNAC) and the resection outcome of SCR.MethodsData were reviewed from 142 type II PSOCs who underwent SCR in Jiangsu Institute of Cancer Research between 1996 and 2016. Among them, 55 cases received preliminary Platinum based SNAC before SCR. Logistic regression analysis was used to explore optimal SCR related factors. Cox proportional hazards model and log-rank test were used to assess the associations between the survival durations and covariates.ResultsOptimal initial CRS (p = 0.02), disappearance of ascites after SNAC (p = 0.04) recurrent status (p = 0.02) and longer Platinum-free interval (p = 0.01) were the independent indicators of optimal SCR. Optimal SCR was associated with time to progression (TTP) but not overall survival (OS) (p = 0.04 and p = 0.41). The TTP and OS of PSOCs underwent SNAC were similar to those patients underwent SCR (p = 0.71, and p = 0.77, respectively) directly.ConclusionsSNAC might be another choice for PSOCs were not suitable for directly SCR. Optimal SCR had survival benefit in PSOCs whenever underwent SNAC or not.
Highlights
The prognostic value and optimal resection outcome related factors of the secondary cytoreduction surgery (SCR) in Platinum-sensitive recurrent ovarian cancer (PSOC) patients were still in doubt
The adequate selection of women with PSOC for surgery is crucial due to the primary goal of SCR aiming at achieving complete gross resection [13,14,15]
One hundred forty-two type II PSOCs who underwent SCR at the Department of Gynecology Oncology in Jiangsu Institute of Cancer Research (JICR) were identified between January 1, 1996 and December 31, 2016
Summary
The prognostic value and optimal resection outcome related factors of the secondary cytoreduction surgery (SCR) in Platinum-sensitive recurrent ovarian cancer (PSOC) patients were still in doubt. The adequate selection of women with PSOC for surgery is crucial due to the primary goal of SCR aiming at achieving complete gross resection [13,14,15]. Several score systems such as AGO, Tian and MSK [16,17,18] was used to enroll PSOCs for this potentially morbidity risk procedure. Our previous study revealed that biochemical relapse guided asymptomatic PSOC optimized the SCR [19]
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