Abstract
Background. Safflower Yellow Injection has been reported as a treatment for acute cerebral infarction in recent studies in China. However, there is a lack of availability of the evidence for the efficacy and safety of Safflower Yellow Injection for the treatment of acute ischemic stroke. So we investigated the effects of Safflower Yellow Injection for the treatment of acute cerebral infarction. Method. All subjects were randomly divided into Safflower Yellow Injection group given Safflower Yellow Injection (80 mg) and control group given placebo (0 mg) injection by intravenous drop once daily for 14 days. National Institute of Health Stroke Scale (NIHSS); hemorheological detection; coagulation function; and serum inflammatory markers, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), were used to investigate the effects before and 14 days after the treatment. Results. The scores of NIHSS were decreased on day 7 and day 14 after treatment. The hemorheological index of RBC deformation and RBC aggregation were significantly improved, prothrombin time (PT) increased, and fibrinogen (FIB) and TNF-α, IL-1β, and IL-6 were decreased in patients treated with Safflower Yellow injection on day 14 after treatment (P < 0.05). Conclusion. Data suggests that Safflower Yellow Injection therapy may be beneficial for acute cerebral infarction.
Highlights
Stroke is a leading cause of death and disability worldwide [1]
These results suggest that Safflower Yellow Injection has protective effect; the reason may be that Safflower Yellow Injection can reduce whole blood viscosity and plasma viscosity, improve index of RBC deformation, reduce index of RBC aggregation, improve microcirculation, and improve brain following ischemic reperfusion in the acute cerebral infarction; the protective effect of hydroxysafflor yellow A in ischemic stroke has been investigated in previous studies [18]
We found that the value of prothrombin time (PT) increased in the Safflower Yellow Injection group after treatment and the values of FIB decreased in the Safflower Yellow Injection group after treatment, and there were significant differences between the two groups
Summary
Stroke is a leading cause of death and disability worldwide [1]. Despite improvements in acute stroke care-stroke unit care, thrombolysis in appropriately selected patients and early and sustained antiplatelet therapy-many patients only makes a partial or poor recovery after stroke and the major burden of stroke is chronic disability [2]. Safflower Yellow Injection has been reported as a treatment for acute cerebral infarction in recent studies in China. There is a lack of availability of the evidence for the efficacy and safety of Safflower Yellow Injection for the treatment of acute ischemic stroke. We investigated the effects of Safflower Yellow Injection for the treatment of acute cerebral infarction. The hemorheological index of RBC deformation and RBC aggregation were significantly improved, prothrombin time (PT) increased, and fibrinogen (FIB) and TNF-α, IL-1β, and IL-6 were decreased in patients treated with Safflower Yellow injection on day 14 after treatment (P < 0.05). Data suggests that Safflower Yellow Injection therapy may be beneficial for acute cerebral infarction
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