Abstract
Background: In recent years, the incidence of prostate cancer (PCa) is increasing. Advanced PCa has a poor prognosis and high cost, which seriously affects the quality of life of patients. Therefore, how to improve the diagnosis rate and prognosis of early PCa is the focus of clinical research. This paper aims to investigate the value of P504s, 34βE12, Ki-67 and prostate-specific antigen (PSA) in the diagnosis and prognosis of PCa.
 Objective: To investigate the expression of P504s, 34βE12, Ki67 and PSA in prostate tissues and their clinical significance.
 Methods: Twenty four cases in the study group were selected from PCa confirmed by pathology in the urology department of Chengde Affiliated Hospital from October 2018 to August 2020, and 33 cases of Benign Prostate Hyperplasia (BPH) confirmed by pathology in the same period were selected as the control group. The expression of P504s, 34βE12 and Ki-67 in prostate tissues were determined by immunohistochemistry.
 Results: The positive expression rates of P504s, 34βE12 and TPSA or F/TPSA in PCa patients were 95.8%, 12.5% and 87.5%, respectively. The positive rates in BPH patients were 9.1%, 93.9% and 27.3%. The difference between the two groups was statistically significant (p<0.05). PCa bone or lymph node metastasis was positively correlated with Ki-67 (r=0.423, p<0.05) and Gleason score (r=0.446, p<0.05), indicating a stronger correlation with Gleasonscore.
 Conclusion: The combined detection of P504s, 34βE12 and PSA is helpful for the diagnosis and differential diagnosis of PCa. High Gleason score and ki-67 expression may indicate high risk of PCa metastasis and poor prognosis.
Highlights
In American men, PCa is the most common nonskin malignant tumor and the second leading cause of death among cancer patients
The combined detection of P504s, 34βE12 and prostate-specific antigen (PSA) is helpful for the diagnosis and differential diagnosis of PCa.High Gleason score and ki-67 expression may indicate high risk of PCa metastasis and poor prognosis
Indexes related to PCa screening, and single test has its limitations.There are few studies on the relationship between P504s, 34βE12, Ki-67 and PSA and PCa.In this study, the expression of P504s, 34βE12, Ki-67 and PSA in prostate tissue was detected to explore the role of P504s, 34βE12, Ki-67 and PSA in the diagnosis and differential diagnosis of PCa and to understand its relationship with metastasis risk and prognosis of PCa
Summary
In American men, PCa is the most common nonskin malignant tumor and the second leading cause of death among cancer patients. The diagnosis and treatment of PCa patients with different degrees of malignancy is a major difficulty, and only active screening can prevent the progression of PCa from the early stage to the incurable stage.At present, there are many test indexes related to PCa screening, and single test has its limitations.There are few studies on the relationship between P504s, 34βE12, Ki-67 and PSA and PCa.In this study, the expression of P504s, 34βE12, Ki-67 and PSA in prostate tissue was detected to explore the role of P504s, 34βE12, Ki-67 and PSA in the diagnosis and differential diagnosis of PCa and to understand its relationship with metastasis risk and prognosis of PCa. In recent years, the incidence of prostate cancer(PCa) is increasing. This paper aims to investigate the value of P504s, 34βE12, Ki-67 and prostate-specific antigen (PSA) in the diagnosis and prognosis of PCa
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