Abstract
The aim of this study was to investigate the value of multiple parameters retrieved from the FDG PET/CT studies, including SUVmax, SUVmean, SUVpeak, MTV, TLG, tumour size in differentiating retroperitoneal paragangliomas from UCD. 28 patients with solitary retroperitoneal masses who had undergone preoperative 18F-FDG PET/CT were retrospectively evaluated. Histopathology by surgical resection confirmed 17 paragangliomas and 11 UCDs. SUVmax, SUVmean, SUVpeak, MTV, TLG, and tumour size of 18F-FDG PET/CT were measured for each patient. Mann–Whitney U-test was used to assess differences in multiple parameters between paragangliomas and UCDs. The ROC curve analysis was performed to determine the differential diagnostic value of these parameters. Paragangliomas presented significantly higher SUVmax (P < 0.001), SUVmean (P = 0.001), SUVpeak (P < 0.001), and TLG (P = 0.024) than UCDs, whereas no significant difference was observed in MTV. The AUCs for differentiating paragangliomas and UCDs were 0.920, 0.888, 0.909, and 0.765 for SUVmax, SUVmean, SUVpeak, and TLG, respectively. The SUVmax cut-off of 7.75 yielded 82.4% sensitivity and 100% specificity for predicting paragangliomas. This study indicated that 18F FDG PET/CT-derived multiple metabolic parameters are useful in distinguishing between paragangliomas and UCDs. SUVmax showed the best result for the differential diagnosis of these two diseases among multiple metabolic parameters.
Highlights
Paragangliomas of the retroperitoneum are closely related to the inferior vena cava and aorta following the aortasympathetic chain[1]
The description of fluorodeoxyglucose (FDG) positron emission tomography/ computed tomography (PET/ Computed Tomography (CT)) features of retroperitoneal paragangliomas and UCDs has been reported on case reports or small series in the literature, and no joint assessment has been performed before for the PET/CT appearances of these two diseases
The aim of this retrospective study was to investigate whether 18F-FDG PET/CT-derived metabolic parameters played a role in differentiating retroperitoneal paragangliomas from UCDs
Summary
Paragangliomas of the retroperitoneum are closely related to the inferior vena cava and aorta following the aortasympathetic chain[1] They can be classified into functional and non-functional paragangliomas, and functional tumors are often associated with the symptoms of hypertension, tachycardia, headache, and diaphoresis[2]. Non-functional paragangliomas can be completely clinically silent, and the levels of catecholamines have been found to be normal in these cases. The description of fluorodeoxyglucose (FDG) positron emission tomography/ computed tomography (PET/ CT) features of retroperitoneal paragangliomas and UCDs has been reported on case reports or small series in the literature, and no joint assessment has been performed before for the PET/CT appearances of these two diseases. We compared the diagnostic value of metabolic parameters to identify the one with the highest diagnostic value in the differential diagnosis of these two diseases
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