Abstract
The article presents a literature review, which provides data on the role of interferons in the immunopathogenesis of COVID-19 and the clinical efficacy of drugs based on recombinant interferon-alpha 2b in the treatment of children with new coronavirus infection. Shown the leading role ofinterferons as factors of the first line of defense against various viruses, including SARS-CoV-2. Numerous studies have proven the feasibility of including interferon preparations in COVID-19 therapyregimens in children, both as combinations with antiviral agents and as monotherapy.
Highlights
The article presents a literature review, which provides data on the role of interferons in the immunopathogenesis of COVID-19 and the clinical efficacy of drugs based on recombinant interferon-alpha 2b in the treatment of children with new coronavirus infection
Numerous studies have proven the feasibility of including interferon preparations in COVID-19 therapy regimens in children, both as combinations with antiviral agents and as monotherapy
Многие иностранные и отечественные авторы подтверждают известный тезис о том, что важнейшими элементами врожденной противовирусной защиты организма являются интерфероны I типа (ИФН-α, ИФН-β), продуцируемые всеми ядерными клетками в ответ на внедрение чужеродной генетической вирусной информации, которые обеспечивают экспрессию интерфероностимулированных генов для потенцирования противовирусных адаптивных реакций в инфицированных и ближайших неинфицированных клетках, таких как стимуляция антигенпрезентирующих функций макрофагов, увеличение продукции цитокинов, усиление активности натуральных киллеров (NK-клеток) и дендритных клеток
Summary
The article presents a literature review, which provides data on the role of interferons in the immunopathogenesis of COVID-19 and the clinical efficacy of drugs based on recombinant interferon-alpha 2b in the treatment of children with new coronavirus infection. R. Samitova1,2 1 Russian Medical Academy of Continuig Professional Education of the Ministry of Healthcare of the Russian Federation, Moscow, Russia 2 Children's city clinical hospital of Z.A. Bashlyayeva of the Moscow Department of health, Moscow, Russia
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