Abstract
Objective To investigate the value of Helicobacter pylori (HP), blood carcinoembryonic antigen (CEA), carbohydrate antigens 72-4 (CA72-4) and CA24-2 in the screening of gastric cancer. Methods The contents of HP, blood CEA, CA72-4 and CA24-2 in 50 healthy controls, 45 patients with benign gastric lesions and 70 patients with gastric cancer were detected. According to the number of positive cases, the positive rate of single detection and the positive rate of combined detection were calculated. Sensitivity, specificity, and accuracy of serum tumor markers were calculated according to HP single and combined detection. Results The positive rate of each individual detection and 4 joint detection in gastric cancer group was significantly different from that in the benign lesion group and the normal control group (P 0.05). The sensitivity, specificity and accuracy of HP, blood CEA, CA72-4, CA24-2 joint detection were significantly higher than single detection (P<0.05). Conclusions Joint detection was significantly better than single detection, and can significantly improve the detection rate of gastric cancer. Key words: Helicobacter pylori; Carcinoembryonic antigen; Antigens, tumor-associated, carbohydrate; Stomach neoplasms/DI
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