Abstract
Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterised by local exocrine glandular involvement and systemic multiorgan manifestations. In this review we will discuss the value of the histological examination of the salivary glands in the classification criteria, and more recently as prognostic tool for patient stratification and monitoring. The limitations of the current tools used to assess salivary gland pathology in pSS will also be reviewed in relation to using salivary gland biopsy analysis as an outcome measure in clinical trials.
Highlights
Progressive loss of the glandular parenchyma [1]
The performance of a salivary gland biopsy and the relevant histological examination is critical for a number of patients who present with negative extractable nuclear antigen (ENA) antibodies [31]
Other elements such as proteomic/seric biomarkers and ultrasound examination of the glands have the potential to be integrated with the information obtained by the histological examination
Summary
The value of histopathological examination of salivary gland biopsies in diagnosis, prognosis and treatment of Sjögren's Syndrome. Document Version Publisher's PDF, known as Version of record Citation for published version (Harvard): Barone, F, Campos, J, Bowman, S & Fisher, BA 2015, 'The value of histopathological examination of salivary gland biopsies in diagnosis, prognosis and treatment of Sjögren's Syndrome', Swiss medical weekly, vol 145, w14168.
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