The value of heparin-binding protein in predicting urosepsis after endoscopic lithotripsy for upper urinary tract stones

Abstract

Objective To investigate the value of heparin-binding protein( HBP ) in predicting urosepsis after endoscopic lithotripsy for upper urinary tract stones. Methods From January to November 2018, 635 cases of upper urinary tract stones treated by endoscopic lithotripsy in our hospital was analyzed. According to the 2014 edition Chinese Guidelines of the diagnosis and treatment of urosepsis, all patients were divided into two groups, the definite urosepsis group (n=53, 8.3%) and the no urosepsis group (n=582, 91.7%). The serum of HBP level was detected by fluorescence immunoassay technology. The serum of procalcitonin (PCT) level was detected by cyclic enhanced immunofluorescent assay. C-reactive protein (CRP) level was detected by automatic chemiluminescence immunoassay analyzer. White blood cells (WBC) count was performed by hematology analyzer. Receiver operating characteristic(ROC) curves were constructed by SPSS 22 and MedCale, and areas under curves (AUC) were calculated and compared to illustrate the diagnostic power of HBP, PCT, CRP and WBC. The correlation between HBP and WBC was also significant (r=0.68, P<0.05). Results The level of HBP, PCT, CRP and WBC were significantly higher in the definite urosepsis group compared to the no urosepsis group. AUC of HBP, PCT, CRP and WBC were 0.930, 0.878, 0.727 and 0.617. When the cutoff of HBP, PCT, CRP and WBC were set as 51.5 ng/ml, 0.41 ng/ml, 64.2 mg/L and 11.7×109/L, the sensitivities were 89.2%, 83.3%, 83.5% and 44.7%, and the specificity were 95.9%, 75.6%, 64.3% and 77.1%, respectively. Conclusions The value of heparin-binding protein was superior to that of PCT, CRP and WBC in predicting urosepsis after endoscopic lithotripsy for upper urinary tract stones. Heparin-binding protein could be acted as a diagnostic marker for urosepsis. Key words: Heparin-binding protein; Upper urinary tract stones; Endoscopic lithotripsy; Urosepsis