The value of detecting perioperative plasma D-dimer level in patients with esophageal cancer or esophageal gastric junction cancer

Abstract

Objective To evaluate the value of detecting the perioperative plasma D-dimer level in patients with esophageal cancer or esophageal gastric junction cancer. Methods 71 patients with esophageal carcinoma or esophageal gastric junction cancer who received operation were enrolled in this study.Plasma D-dimer lever before the operation and on 1st,4th,7th,10th day postoperation were detected and to find the relation between the D-dimer level and patients clinical characters. Results Plasma D-dimer lever before the operation was higher when the stage was later in esophageal cancer or in the esophageal gastric junction cancer[stage 0:(141. 5±71. 4)μg/L; stageⅠ:(205. 5± 89. 0)μg/L;stageⅡ:(267. 1±123. 4)μg/L;stageⅢ:(446. 5±227. 9)μg/L;stageⅣ:(289. 0± 0. 0)μg/L], and there was no relation with other clinical characters.Plasma D-dimer level reach the max on 1st day postoperation[(1 193. 0±670. 5)μg/L], and decreasing on 4th day[(893. 2± 287. 5)μg/L]; it rise again on 7th day postoperation[(1 089. 1±178. 9)μg/L], and then drop down on 10th day[(1 043. 8±202. 9)μg/L]. Conclusion Plasma D-dimer lever before the operation was positive relative with the stage of esophageal cancer or esophageal gastric junction cancer. Plasma D-dimer level rise after operation.It reach max on 1st day because the surgical trauma and microthrombus, and decrease signicicantly on 4th day.It rise again on 7th day,and then,it decrease gradually.If it rise after 7 days postoperation, deep venous thrombosis(DVT) and pulmonary thromboembolism(PTE)should be considered. Key words: Esophageal carcinoma; Esophageal gastric junction cancer; D-dimer; Perioperative