Abstract
BackgroundThe human Y-box-binding protein 1 (YB-1) is a member of the DNA/RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer.MethodsImmunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed.ResultsHormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (≥14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p < 0.05). Although there was no significant difference in relapse-free survival (RFS) between the two groups (p = 0.412), difference in overall survival (OS) was statistically significant (p = 0.035). In multivariate analysis for OS, YB-1 was an independent prognostic factor (p = 0.043).ConclusionThis suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics. Expression of cytoplasmic YB-1 in cancer cell could be used as an independent prognostic marker for predicting OS in breast cancer.
Highlights
Breast cancer is the most common cancer for women and its incidence is gradually increasing [1]
In multivariate analysis for overall survival (OS), Y-box-binding protein 1 (YB-1) was an independent prognostic factor (p = 0.043). This suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics
It was reported that the expression of YB-1 increases in cancer cells and its high expression or expression in nucleus were associated with poor prognosis in many types of cancer [6,7,8,9, 13]
Summary
Breast cancer is the most common cancer for women and its incidence is gradually increasing [1] It is a kind of heterogeneous disease due to its broad spectrum of morphological features, clinical manifestations, and treatment responses [2]. It needs various makers for predicting prognosis and many previous studies have searched for new markers for prognosis and treatment in breast cancer. The human Y-box-binding protein 1 (YB-1) has been suggested as a new prognostic marker in many studies. The process that cold shock domain of YB-1 binds with the Y-box in the gene promoter regulates gene transcription and translation. We evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer
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