Abstract
Coronary CT angiography (CTA) with the characteristics of noninvasive and simple operation is widely used in the diagnosis of coronary artery stenosis. The choice of contrast agent exerts an important impact on the imaging quality of CTA. Conventional iodine contrast agents are easily excreted by the kidneys, from which the imaging window is short, and the imaging quality is poor. Metal nanomaterials have unique optical properties and have broad application prospects in imaging. Our aim is to explore the value of gold nanorod contrast agent in the diagnosis of coronary heart disease. A gold nanorod suspension was first prepared, and the prepared gold nanorod was uniform and had good dispersibility. It can be seen from the light absorption curve that there are two obvious peaks on the UV absorption peak of the gold nanorods. The gold nanorods were cultured in different solutions, and it was found that the particle size of the gold nanorods did not change significantly within 72 hours, indicating that the prepared gold nanorods had good stability. When observing the damage degree of mouse kidney tissue, it was shown that the damage degree of gold nanorod contrast agent to mouse kidney tissue was less than that of iodine contrast agent. The above results indicate that the gold nanorod contrast agent has good stability and safety. Therefore, our study demonstrated that the gold nanorod contrast agent has high value in the diagnosis of coronary arteries and the analysis of plaque properties.
Highlights
In recent years, due to more high-risk factors for cardiovascular disease, the incidence cardiovascular disease has continued to rise [1]
Coronary heart disease refers to the blood lipids depositing on the arterial intima due to abnormal body lipid metabolism, causing vascular lumen stenosis or occlusion, which leads to myocardial hypoxia, ischemia, or necrosis [3,4,5]
Some other researches have stated that the signal-to-noise ratio of rhenium sulfide nanoparticle contrast agent is higher than that of iodine contrast agent, and the use of rhenium sulfide nanoparticle contrast agent in CT imaging can improve the contrast of gastrointestinal imaging in patients [21]
Summary
Due to more high-risk factors for cardiovascular disease, the incidence cardiovascular disease has continued to rise [1]. According to relevant epidemiological survey data, cardiovascular disease has become one of the main causes of human death, and the diseased population continues to be younger [2]. Coronary heart disease refers to the blood lipids depositing on the arterial intima due to abnormal body lipid metabolism, causing vascular lumen stenosis or occlusion, which leads to myocardial hypoxia, ischemia, or necrosis [3,4,5]. If the myocardial state can be accurately assessed in the early stages of coronary heart disease, targeted measures can be taken to reduce the risk of disability or death in patients. The current medical community believes that the nature of coronary artery plaque is closely related to the development of the disease. Analyzing the nature of coronary artery plaque in patients with coronary heart disease is of great significance for reducing the risk of cardiovascular disease
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