The Value of Contrast-Enhanced Ultrasound Features in Predicting HER2 Positive and Ki67 High Expression in Invasive Breast Cancer of No Special Type

Abstract

Objective: To investigate the value of contrast-enhanced ultrasound features in predicting HER2 positive and Ki67 high expression in invasive breast cancer of no special type. Methods: Retrospective analysis was conducted on the correlation between contrast-enhanced ultrasound images of 92 patients with invasive breast cancer of no special type confirmed by pathology in our hospital and the expression of HER2 and Ki67, including 64 cases in the HER2 negative group and 28 cases in the positive group. Ki67 expression was low in 14 cases and high in 78 cases. The contrast-enhanced ultrasound indicators include: BI (Base Intensity), AT (Arrival Time), TTP (Time To Peak), PI (Peak Intensity), AS (Ascending Slope), DT/2 (Descending Time/2), DS (Descending Slope), AUC (Area Under Curve), maximum focal area ratio of before and after contrast-enhanced ultrasound (AR Area Ratio), Distance of anterior boundary of lesion to skin after contrast-enhanced ultrasound (DTS Distance to skin) and maximum diameter after contrast-enhanced ultrasound (D Diameter), and the above indexes were compared and analyzed in the negative and positive groups of HER2, and the low and high expression groups of Ki67. Results: Logistics regression analysis showed that DTS is an independent risk factor for HER2 positive (P＜0. 05). AR was an independent risk factor for Ki67 high expression (P＜0. 05). Conclusion: The combination of contra-enhanced ultrasound features has high diagnostic efficacy for HER2 positive and Ki67 high expression, which can provide an important reference.