The value of combined detection of LP-PLA2 and sd-LDL in the auxiliary diagnosis of atherosclerosis

Abstract

Objective To investigate the auxiliary diagnostic value of combined detection serum lipoprotein-associated phospholipase A2 (LP-PLA2) and small and dense low-density lipoprotein (sd-LDL) in atherosclerosis. Methods The subjects were divided into experimental group and control group by random block design from May 2017 to January 2018, in the First Affiliated Yijishan Hospital of Anhui Wannan Medical College. The experimental group selected 125 AS patients with clinical diagnosis and confirmed by angiography, and 55 healthy subjects were chosen as the normal control group at the same time. Serum samples were collected within 24 hours after admission, and the level of LP-PLA2, sdLDL-C, low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC) and high-sensitive C reactive protein(hs-CRP) were unified detection. The t test, single factor variance analysis and Mann-Whitney U and multivariate logistic regression analysis were used to analyze the data. Results LP-PLA2, sd-LDL, LDL, TC, TG and hs-CRP of the AS group were all higher than those of the healthy control group (Z=5.279,6.663,6.012,5.863,5.508 and 2.845, respectively, P 0.05). Conclusions sd-LDL combined with LP-PLA2 has high sensitivity and specificity in the prediction of AS, which makes up for the deficiency of individual detection; sd-LDL and LP-PLA2 serum level has nothing to do with the lesion and has a positive correlation with the degree of lesions. It is not easily affected by other risk factors and can be used as a risk factor for predicting the occurrence of AS. Key words: Atherosclerosis; 1-Alkyl-2-acetylglycerophosphocholine esterase; Lipoproteins, LDL; Risk factors