Abstract
Gastroesophageal reflux disease (GERD) is the most common gastrointestinal disorder in the Western world. Proton pump inhibitors are the most important treatment option for these patients. However, some patients are reluctant to take long-term medication. As an alternative, several endoscopic antireflux procedures have been developed. Initial feasibility studies and a few randomized, controlled studies have demonstrated promising results and short-term efficacy, but longer follow-up studies have failed to show a persistent benefit for most of these interventions. Three devices already have been withdrawn because of lack of efficacy or concerns about safety. We conclude that scientific and clinical data on safety, efficacy, and durability are insufficient to support the use of endoscopic therapies for GERD in routine clinical practice. Endoscopic therapies for GERD should be offered only under well-defined study conditions. For now, antisecretory medication remains the standard approach to treat patients with GERD.
Published Version
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