Abstract
The value of ADC calculations in the assessment of the early response of hepatocellular carcinoma (HCC) to trans arterial catheter chemoembolization (TACE).
Highlights
Detection and treatment of residual viable hepatocellular carcinoma (HCC) tissue will significantly have a positive impact on long term results and improvement of patient survival.[1]
In correlation of early response of HCC lesions by apparent diffusion coefficient (ADC) values of treated lesions compared to contrast enhanced studies based on mRECIST, The following was obtained; Complete Response (CR) patients had highest postoperative ADC levels and 80% of the lesions showed unequivocal increased ADC with average increase about 48% otherwise 20 % showed minimal increase in ADC value that was statistically not significant
It was found that the specificity of degree of ADC change is maximized by gaining at least 22% increase in ADC value, and the sensitivity is maximized by gaining less than 15% increase in ADC
Summary
Detection and treatment of residual viable HCC tissue will significantly have a positive impact on long term results and improvement of patient survival.[1]. Different imaging modalities are used in the assessment of tumor response to TACE, typically contrast enhanced CT or MRI imaging, and functional response based on MRIDWI.[2]. DWI with corresponding ADC levels based on the free mobility of water molecules in tissues as intact necrotic cells with lost membrane integrity allow facilitation of water molecules mobility reflecting a realistic image about tumor internal changes after treatment in terms of tumor necrosis.[3]
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