Abstract
Radioactive tagging of chemicals has given the investigator a means of simplifying tests for many physiologic functions. Quantitative assays of renal function hitherto have been cumbersome, and to some degree hazardous, in view of the possible introduction of infection if bladder catheterization must be employed. Yet greater accuracy in the study of split renal function is now more important than ever, with the increased interest in surgical corrective measures, particularly for renovascular hypertension. With these considerations, a study was undertaken with the following objectives: (a)To determine whether or not a radioactive clearance study technic could be developed which would parallel standard technics. (b)To determine whether or not such a technic could be adapted to human use without subjecting the patient to excessive radiation from large amounts of the labeled compound. (c)To simplify the basic technic to a single intravenous injection, with avoidance of catheterization through the use of exter...
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