Abstract
Fractional flow reserve(FFR) measured under hyperemic conditions has been the gold standard for measuring the functional significance of stenosis. Recently, saline induced distal coronary pressure/aortic pressure ratio predicts an FFR. The resting full-cycle ratio(RFR) represents the maximal
Highlights
It remains unclear whether saline-induced resting full-cycle ratio (RFR) can predict fractional flow reserve (FFR). erefore, the present study aimed to compare the results of saline-induced RFR with FFR
Seventy consecutive cardiac lesions with more than moderate stenosis based on visual estimation by coronary angiography were included in this study. e FFR, RFR, and saline-induced RFR (sRFR) were measured to identify functionally significant stenosis
MN, USA), the wire was advanced into the site distal to the stenosis. e study procedure was as follows: First, the RFR was automatically measured at resting status twice. e mean of the two values was adopted as the RFR value
Summary
Seventy consecutive cardiac lesions with more than moderate stenosis (exceeding 30%) based on visual estimation by coronary angiography were included in this study. E FFR, RFR, and sRFR were measured to identify functionally significant stenosis. We intravenously administered 100 IU/kg of heparin before coronary angiography was performed. E study procedure was as follows: First, the RFR was automatically measured at resting status twice. After the RFR measurement, the sRFR was assessed by an intracoronary bolus of saline at room temperature at 2 mL/second for 5 heartbeats through the catheter using a. E correlations between 2 factors among sRFR, RFR, Pd/Pa, and FFR values were evaluated using the Spearman rank correlation coefficient. The receiver operating characteristic (ROC) curve analysis was used to identify the sRFR cutoff value for predicting an FFR value ≤0.80. A twosided p value
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