The utility of magnetic resonance imaging in the evaluation of arrhythmogenic right ventricular cardiomyopathy

Abstract

Perceptions of the utility of cardiovascular magnetic resonance in the evaluation of arrhythmogenic right ventricular cardiomyopathy have changed considerably in the past decade. This review offers an up-to-date perspective on the diagnostic role of cardiovascular magnetic resonance in the genetics era. Originally hailed as a putative gold standard in arrhythmogenic cardiomyopathy, cardiovascular magnetic resonance has received a more guarded reception lately owing to interobserver variability and lack of standardized protocols. Recent studies have nonetheless affirmed its value as an integral component of the diagnostic work-up. Quantitative volume analysis is relatively robust, but visualization of myocardial fat by spin-echo imaging is less reliable. Interpretation of wall motion abnormalities appears reproducible among expert readers. Emerging data suggest a key role for late gadolinium enhancement in detection of left ventricular involvement. Cardiovascular magnetic resonance in arrhythmogenic cardiomyopathy is facilitated by appropriate patient selection and preparation, experienced readers and operators, and a dedicated, comprehensive protocol. Indications for magnetic resonance assessment include proven arrhythmogenic cardiomyopathy in the family, unexplained ventricular arrhythmia, inverted T-waves in the right precordial or lateral leads, and/or family history of sudden cardiac death. Arrhythmia suppression is essential for optimal electrocardiographic triggering and image acquisition.