Abstract
The Utility of Concentric Needle Single Fiber Electromyography in Diagnosing Myasthenia Gravis
Highlights
Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder, characterized by varying degrees of fluctuating muscular weakness and fatigability
Abnormal Concentric Needle Electrode (CNE)-Single Fiber Electromyography (SFEMG) results were detected in 79.1%, 77% and 82.4% of all MG, generalized MG (GMG) and ocular MG (OMG) patients respectively
CNE-SFEMG had a sensitivity of 79.1 % and specificity of 51.6 % in all MG patients with 67.6% test accuracy
Summary
Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder, characterized by varying degrees of fluctuating muscular weakness and fatigability. Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder, characterized by varying degrees of fluctuating weakness and fatigability of the skeletal muscles without loss of reflexes or impairment of sensation or any other neurologic function [1]. It is a relatively common neurological disease resulting from an antibody-mediated neuromuscular transmission defect, where antibodies are directed against the muscle nicotinic acetylcholine receptors (AChR) or, sometimes, against other post junctional components such as the muscle specific kinase (MuSK) which indirectly decreases the AChR numbers [2, 3]. Few patients may present with neuromuscular respiratory failure from the onset [4]
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