The Using of Cryodestruction Methods in the Treatment of Primary Liver Cancer

Abstract

Objective: to improve treatment outcomes, quality and life expectancy in patients with primary liver cancer. Materials and methods: Since 2012, cryodestruction (CD) was performed in 14 patients with primary liver cancer, in 6 patients with hepatocellular cancer (HCR) and 8 patients with cholangiocellular cancer (CCR), 5 women and 8 men. The size of the lesions in the liver was 2-8 cm, the number of lesions was 1-8 (3±2). The exposure time was 3-5 min, the exposure temperature was -186С. CD in combination with RFA was performed in 5 patients, CD+liver resection-in 2 patients, a CD+RFA+liver resection - in 2 patients. All patients were subsequently given adjuvant chemotherapy. Results: Severe life-threatening complications were observed in 2 (7.1%) operated patients: - 1 (7.1%) intra-abdominal bleeding, 1 - death due to progression of multiple organ failure during sepsis after application of CD in combination with liver resection and RFA. Survival in patients after the use of cryodestruction in combination with other methods of local destruction was 20.5±5 months, after cryodestruction - 12.56±3 months. (p < 0.05). Survival in patients after the use of cryodestruction in combination with other methods of local destruction with CCR was 9.2±4.5 months (p < 0.05), with cryodestruction - 7 + 2.5 months. (p < 0.05). Conclusion: Cryodestruction in combination with other methods of local destruction in primary liver cancer in unresectable patients is an intervention that significantly improves the quality of life of cancer patients. When using adjuvant chemotherapy, there is also a slight improvement in survival rates.