Abstract
PurposeTo evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment.MethodsBest-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (ΔBCVA1m), mean sensitivity in the most affected quadrant at 1 month (ΔqMS1m), MV in the most affected quadrant at 1 month (ΔqMV1m), and CRT at 1 month (ΔCRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified.ResultsThere was not a significant difference in BCVA (paired Wilcoxon test, p = 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (p < 0.05). There was a significant relationship between ΔqMS1m and ΔMV1m, ΔCRT1m, and ΔqMV1m, respectively. ΔMS1m or ΔqMS1m and BCVA at baseline and ΔBCVA1m were selected as explanatory variables in the optimal model for BCVA3m.ConclusionRetinal sensitivity was related to retinal structure, whereas this was not the case with BCVA. In addition, retinal sensitivity was useful to predict BCVA after anti-VEGF therapy.
Highlights
Retinal vein occlusions (RVOs) are one of the most common retinal vascular diseases [1]
Retinal sensitivity measurement with MP3 microperimetry was performed in patients with branch retinal vein occlusion (BVO) and macular edema (ME) before and after the anti-VEGF treatment, along with 1 month after treatment
The change of retinal sensitivity was correlated with retinal volume especially in the affected quadrant; on the other hand, visual acuity was not correlated with retinal structure
Summary
Retinal vein occlusions (RVOs) are one of the most common retinal vascular diseases [1]. City University, Yokohama, Kanagawa, Japan (BVO), patient’s sights are threatened by various associated complications, including macular edema (ME). ME in RVOs is usually treated with the intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents as the first-line therapy [2,3,4,5,6]. Previous studies suggested that retinal sensitivity measured with perimetry is associated with OCT-measured macular structural change, using the Humphrey Field Analyzer (HFA, Carl-Zeiss Meditec AG, Dublin, CA, USA) [3] and the MP1 Microperimeter (Nidek CO., LTD, Aichi, Graefes Arch Clin Exp Ophthalmol (2020) 258:1949–1958
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Graefe's Archive for Clinical and Experimental Ophthalmology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
