Abstract
Prostate cancer is a multifactorial disease and the second most common cancer diagnosed in men worldwide. The six transmembrane epithelial antigen of prostate (STEAP) proteins seem to be involved in prostate tumorigenesis. The STEAP proteins are differentially expressed in prostate cancer cells, and survival analysis reveal that prostate cancer patients with high levels of STEAP1 have poor survival outcomes. In contrast, high expression of STEAP4 offers a better prognosis. This chapter provides an overview of the role of STEAP proteins in prostate cancer. The structure, biological functions, and the potential prognostic significance of each of the four members of the STEAP family in prostate cancer are discussed.
Highlights
Prostate cancer is the second most diagnosed cancer and the sixth leading cause of cancer‐related death in men in the Western world
The six transmembrane epithelial antigen of prostate (STEAP) proteins are differentially expressed in prostate cancer cells, and survival analysis reveal that prostate cancer patients with high levels of STEAP1 have poor survival outcomes
Using the same dataset retrieved from the cBioPortal [51], it was found that only STEAP1 overexpression is associated with the overall survival of prostate cancer patients (Figure 3A and Table 3)
Summary
Prostate cancer is the second most diagnosed cancer and the sixth leading cause of cancer‐related death in men in the Western world. The structure, biological functions, and the potential prognostic significance of each of the four members of the STEAP family in prostate cancer are discussed. The clinical significance of the expression of STEAP proteins for prostate cancer development is still scarce, and further analysis is required to ascertain their usefulness as prognostic biomarkers.
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