The usefulness of S100ß protein and fractalkin in predicting traumatic brain injury in pediatric patients with minor head trauma

Abstract

Aims: In this study it was aimed to demonstrate the effectiveness of S100B protein levels which are biomarkers related to central nervous system, and fractalkin levels, which are known to play a role in inflammation processes in prediction trauma induced brain damage. Methods: Patient aged 2 to 18 years who came to the emergency department due to minor head trauma and underwent brain ct were included in our study. It was investigated whether there was a relationship between the two groups, according to the causes of trauma, symptoms at presentation and the level of serum s100b and FCN according to the lesions detected in CCT. Results: The other symptoms including Vomiting, retrograde amnesia, loss of consciousness, confusion, post traumatic amnesia is significantly higher in patients with brain lesions (p<0,05). Patients with lesions on BCT have significantly low Glassgow coma score. (p<0,05). Patients with lesions on BCT have a significantly high S100B and FKN levels. (p<0,05). S100B area under the curve (CUA) 0.700 sensivity is 55%, spesificity is 87.5%. FKN CUA 0,785, sensitivity is 62.5% specifisity is 85%. Conclusions: As a result, the child patients with BCT lesions from minor cranial trauma levels for S100B and FKN levels are significantly higher and can be a criteria for BCT usage in emergency medicine.