Abstract
Aims: In this study, Doppler parameters were studied in patients with advanced stage renal disease, and the relationship between Doppler parameters and renal disease stage was investigated. Doppler values were evaluated for a cut-off value between normal and end-stage kidney disease group. Materials and methods: 50 patients with chronic kidney disease and 15 patients belonging to the same age group and with normal serum creatinine levels were comprised of the study and control groups. Resistivity and pulsatality indices were measured at the main renal arteries and interlobular arteries at both sides. Results: Statistically significant differences were found between the PI and RI values obtained from the main renal and interlobular arteries. PI sums were compared with those from the control group, and a cut-off value of 2.15 was found, with a sensitivity of 90% and a specificity of 86.7%. Conclusion: Any increase in the RI and PI values obtained from the main renal and interlobular arteries must bring to mind the possibility of advancing renal damage and interstitial fibrosis. Patients with and without renal parenchymal damage can be differentiated by means of comparing the total PI values obtained from the right and left main renal and interlobular arteries.
Highlights
Chronic kidney disease is in the course of becoming a bigger major public health issue [1] [2]
The presence of interstitial fibrosis and loss of capillaries and tubules are a general result of progressive renal disease, and glomerular filtration rates (GFR) loss, on the other hand, is closely related with renal functions and long-term prognosis [12]
Izumi et al have reported that the differential diagnosis of acute tubular necrosis and prerenal azotemia may be made by means of the renal resistivity index [16]
Summary
Chronic kidney disease is in the course of becoming a bigger major public health issue [1] [2]. It is of vital importance to predict the late term prognosis of these patients. Some of these predictors are arterial hypertension, proteinuria, and baseline renal function [5]. Interstitial fibrosis supplies valuable predictive data about prognosis. The renal intraparenchymal arterial flow pattern is influenced by structural and functional factors, and the flow wave is created by vascular compliance and resistance. This is why pathological conditions such as interstitial fibrosis have a strong impact on the indices obtained from Doppler examinations [8]. Intra and extrarenal arterial flow Doppler parameters were studied in patients with advanced stage renal disease, and the relationship between Doppler parameters and renal disease stage was investigated
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