Abstract
Sarcoidosis is a multi-systemic granulomatous disease of unknown etiology. The present study has been designed to evaluate the importance of diastolic dysfunction with left atrial volume index (LAVi) and left ventricular mass index (LVMi) in determining subclinical cardiac involvement in subjects with stage I-II pulmonary sarcoidosis. A total of 54 patients under follow-up for sarcoidosis without cardiac involvement and 56 healthy subjects were included in the study. The echocardiographic assessment of the patients revealed no significant difference between the two groups regarding left ventricular end-systolic and end-diastolic diameters, ejection fraction (LVEF) and annular velocity determined by tissue Doppler evaluation. The LVEF calculated was 61.8±7.8% in the sarcoidosis group versus 64.1±2.7% in the control group (p=0.04). Left ventricular interventricular septum thickness, posterior wall thickness, and relative wall thickness were significantly higher in the sarcoidosis group compared to the control group (p<0.001). The sarcoidosis group had higher LVM and LVMi values compared to the control group (145±18.1 and 79±14g/m(2), 135±27.7 and 74±14.2g/m(2); p=0.020 and p=0.021, respectively). Left atrial end-systolic volume and LAVi were higher in the sarcoidosis group (28.7±18.5; 15.6±10.2) compared to the control group (16.6±10.9; 8.9±5.5) with a statistically significant difference (p<0.001). The present study indicates diastolic dysfunction and increased LVMi despite normal systolic function in patients with early-stage sarcoidosis without cardiac involvement. Also, the diastolic parameters were normal without showing any significant difference compared to the control group while there was a statistically significant increase in LAVi. This finding suggests that LAVi may be the earliest marker of diastolic dysfunction in patients with early-stage sarcoidosis without cardiac involvement.
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