Abstract
The dissection of an organ as complex as the mammalian central nervous system will require that its many components be characterized in simpler and more accessible environments. Along these lines, it would appear that at least for the purpose of analysing the structure and function of membrane proteins that regulate neuronal membrane conductances, a surrogate expression system is at hand. Recent studies have shown that the injection of mRNA isolated from electrically excitable tissues into Xenopus oocytes results in the functional expression of many neurotransmitter receptors and voltage-gated ion channels. In addition, Xenopus oocytes provide an excellent assay system for the initial isolation of cDNAs encoding these important molecules.
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