The use of vitamin B12 in the management of the neurologic manifestations of diabetes mellitus, with notes on the administration of massive doses.

Abstract

Article1 November 1951THE USE OF VITAMIN B12 IN THE MANAGEMENT OF THE NEUROLOGIC MANIFESTATIONS OF DIABETES MELLITUS, WITH NOTES ON THE ADMINISTRATION OF MASSIVE DOSESSALVATORE M. SANCETTA, M.D., PERRY R. AYRES, M.D., ROY W. SCOTT, M.D., F.A.C.P.SALVATORE M. SANCETTA, M.D.Search for more papers by this author, PERRY R. AYRES, M.D.Search for more papers by this author, ROY W. SCOTT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-5-1028 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this paper is to report our experiences with the use of parenterally administered vitamin B12 in the management of 12 diabetic patients exhibiting unquestioned neurologic manifestations associated with the disease. We shall not discuss the features of so-called "diabetic neuropathy," other than for the corollaries necessary to our thesis. The reader interested in a detailed presentation of the subject is referred to the classical monograph of Rundles,15 as well as to other excellent treatises available in the literature.3, 14, 16Vitamin B12has been found to arrest6and reverse2the neurologic changes in patients with pernicious anemia,...Bibliography1. BeanFranklinSahs WBMAL: Preliminary note on the effect of vitamin B12 on the painful aspects of nutritional neuropathy, Proc. Central Soc. Clin. Research 22: 10, 1949. Google Scholar2. BerkDenny-BrownFinlandCastle LDMWB: Effectiveness of vitamin B12 in combined system disease, New England J. Med. 239: 328, 1948. CrossrefMedlineGoogle Scholar3. CollensRabinerZilinskyBoasGreenwald WSAMJDLCJJ: The treatment of peripheral neuropathy in diabetes mellitus, Am. J. M. Sc. 219: 482, 1950. CrossrefMedlineGoogle Scholar4. CollerMaddock FAWG: The function of peripheral vasoconstriction, Ann. Surg. 100: 983, 1934. CrossrefMedlineGoogle Scholar5. Furmanski AR: BAL therapy of severe peripheral neuropathies, Arch. Neurol. and Psychiat. 60: 270, 1948. CrossrefMedlineGoogle Scholar6. HallCampbell BEDC: Vitamin B12 therapy in pernicious anemia. II. Effect on the general clinical and neurologic manifestations; preliminary report, Proc. Staff Meet., Mayo Clin. 23: 591, 1948. MedlineGoogle Scholar7. HodgesRundlesHanelin FJRWJ: Roentgenologic study of the small intestine. II. Dysfunction associated with neurologic diseases, Radiology 49: 659, 1947. CrossrefMedlineGoogle Scholar8. HorriganVilter DRW: Direct action of vitamin B12 upon human bone marrow; the effect of instillations of vitamin B12 and folic acid into the bone marrow as studied by histochemical techniques, Proc. Am. Soc. Clin. Investigation 42: 33, 1950. Google Scholar9. Karnosh L: Neurologic phases of diabetes, from: Proceedings Diabetes Course, Cleveland Clin. Quart. 16: 227, 1949. Google Scholar10. Karnosh L: Personal communication. Google Scholar11. MaddockColler WGF: The role of the extremities in the dissipation of heat, Am. J. Physiol. 106: 589, 1933. CrossrefGoogle Scholar12. RabinowitchFowlerWatson IMAFBA: Gastric acidity in diabetes mellitus. Its clinical significance based on a study of one hundred cases, Arch. Int. Med. 47: 384, 1931. CrossrefGoogle Scholar13. Roberts JT: The effect of occlusive arterial diseases of the extremities on the blood supply of nerves. Experimental and clinical studies on the role of the vasa nervorum, Am. Heart J. 35: 369, 1948. CrossrefMedlineGoogle Scholar14. RudyEpstein ASA: Review of one hundred cases of diabetic neuropathy followed for one to ten years, J. Clin. Endocrinol. 5: 92, 1945. CrossrefGoogle Scholar15. Rundles RW: Diabetic neuropathy, Medicine 24: 111, 1945. CrossrefGoogle Scholar16. WoltmanWilder HWRM: Diabetes mellitus: pathologic changes in the spinal cord and peripheral nerves, Arch. Int. Med. 44: 576, 1929. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Portions of this paper were presented as a preliminary report and in abstract form to the sixty-third meeting of the Association of American Physicians, May 3, 1950, Atlantic City, N. J. Received for publication September 27, 1950.From the Department of Medicine, Western Reserve University School of Medicine, City Hospital Division, Cleveland, Ohio.The crystalline Vitamin B12 used in this study has been supplied by the following commercial houses: Merck & Co., Rahway, N. J., Squibb & Sons, New York, N. Y., and Eli Lilly & Co., Indianapolis, Indiana. 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SACKS, M.D.Die Behandlung der diabetischen Polyneuritis mit Vitamin B12Application to Human NutritionVitamin B12 in PracticeDiabetes Mellitus 1 November 1951Volume 35, Issue 5Page: 1028-1048KeywordsDiabetes mellitusHospital medicineNeuropathyPernicious anemia Issue Published: 1 November 1951 PDF downloadLoading ...