Abstract
Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. Here, the author analyses the medical charts of the last 100 patients seen in his clinic, 17 of whom have been taking a very high dose of baclofen, which is to say, more than 300 mg/day. The analysis of the charts shows that the very high-doses baclofen were justified in almost all the cases. Side effects are analyzed.
Highlights
Renaud de Beaurepaire*Reviewed by: Giovanni Martinotti, University G.d’Annunzio, Italy Henriette Walter, University of Vienna, Austria
High-dose baclofen has been shown to produce a remarkable state of indifference toward alcohol [1]
There were four cases of severe side effects: Pt8 was suffering from somnambulism long before treatment, but baclofen worsened his somnambulism, which became associated with nocturnal delirium, and 1 day Pt8 fell during an episode of sleepwalking and broke his ankle
Summary
Reviewed by: Giovanni Martinotti, University G.d’Annunzio, Italy Henriette Walter, University of Vienna, Austria. High-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. Baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. The author analyses the medical charts of the last 100 patients seen in his clinic, 17 of whom have been taking a very high dose of baclofen, which is to say, more than 300 mg/day. The analysis of the charts shows that the very high-doses baclofen were justified in almost all the cases.
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