Abstract
To determine the effectiveness of local antibacterial therapy in preventing ascending vaginal infection after premature rupture of the membranes, 258 patients who were not in labor had inserted into their vaginas a nitrofurazone or placebo suppository (on a double blind basis) every 6 hours until labor ensued and delivery was accomplished. Bacteriologic studies were included. The results, analyzed by comparing the clinical and laboratory evidence of infection, indicated that nitrofurazone did not reduce the risk of amnionitis or the risk of infection of the infant.
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