Abstract
Several known and suspected nephrotoxic agents were administered to male Wistar rats and the excretion rates of 4 enzymes located largely in specific regions of the cell were measured. The excretion of lactate dehydrogenase and alkaline phosphatase in the urine was considerably increased and the severity of the renal damage appeared to be related to the enzyme activity present in the urine. The excretion of acid phosphatase and glutamate dehydrogenase was usually within normal limits or only slightly raised. 4-Aminocatechol, an abnormal metabolite of phenacetin suspected of causing kidney damage, gave normal results for enzyme excretion suggesting the absence of renal lesions in the rat. The value of urinary enzyme measurements to detect acute kidney damage by toxic compounds and to identify the primary renal lesion is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
