The use of Titanium Platelet-Rich Fibrin to Enhance the Treatment Outcome of Intrabony Defect in the Chronic Periodontitis Patients - A Systematic Review and Meta-Analysis

Abstract

Aim and Objective: The aim and objective of the study are to ascertain the use of titanium platelet-rich fibrin (T-PRF) to enhance the treatment outcome of intrabony defect in the chronic periodontitis patients. Methodology: Data resources: Four databases MEDLINE (by PubMed), Cochrane database, EBSCO, and Google Scholar were explored to identify the studies in English from 2015 up to March 2021. An additional hand search of relevant journals was also done. All the reviewers screened the retrieved articles using the particular inclusion criteria. Randomized control trials evaluating the use of T-PRF to enhance the treatment outcome of intrabony defect in chronic periodontitis patients were included in the study. Outcome variables examined were probing pocket depth (PPD) reduction, relative attachment level (RAL) gain, change in gingival index (GI) and plaque index (PI), radiographic depth reduction. Statistical Analysis: Data were analyzed using Revman 5.3 software. The mean differences and 95% confidence interval were used to illustrate the estimate of effect size. Study Selection: five relevant articles were recognized for data procurement. A total of 138 patients had been appraised with confirmation of intrabony defects. In the included studies, age span of participants was between 20 and 59 years. Results: It displayed that the use of T-PRF induced a reduction in PPD, gain in RAL along with open flap debridement (OFD) in the management of intrabony defects. The use of T-PRF along with OFD and OFD only has equal effect on GI and PI. Conclusion: Thus, within the constraints of the study, it implies that T-PRF can be adapted contentedly in conjunction with OFD to deal with the intrabony defect.